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Article Publish Status: FREE
Abstract Title:

The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls.

Abstract Source:

Int J Mol Sci. 2019 Jan 20 ;20(2). Epub 2019 Jan 20. PMID: 30669509

Abstract Author(s):

Jonna Jalanka, Giles Major, Kathryn Murray, Gulzar Singh, Adam Nowak, Caroline Kurtz, Inmaculada Silos-Santiago, Jeffrey M Johnston, Willem M de Vos, Robin Spiller

Article Affiliation:

Jonna Jalanka

Abstract:

Psyllium is a widely used treatment for constipation. It traps water in the intestine increasing stool water, easing defaecation and altering the colonic environment. We aimed to assess the impact of psyllium on faecal microbiota, whose key role in gut physiology is being increasingly recognised. We performed two randomised, placebo-controlled, double-blinded trials comparing 7 days of psyllium with a placebo (maltodextrin) in 8 healthy volunteers and 16 constipated patients respectively. We measured the patients' gastrointestnal (GI) transit, faecal water content, short-chain fatty acid (SCFA) and the stool microbiota composition. While psyllium supplement had a small but significant effect on the microbial composition of healthy adults (increasingand decreasing), in constipated subjects there were greater effects on the microbial composition (increased,,,andand decreased unculturedand) and alterations in the levels of acetate and propionate. We found several taxa to be associated with altered GI transit, SCFAs and faecal water content in these patients. Significant increases in three genera known to produce butyrate,,and, correlated with increased faecal water. In summary, psyllium supplementation increased stool water and this was associated with significant changes in microbiota, most marked in constipated patients.

Study Type : Human Study
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