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Abstract Title:

Pterostilbene inhibits amyloid-β-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway.

Abstract Source:

J Cell Biochem. 2018 May 8. Epub 2018 May 8. PMID: 29737568

Abstract Author(s):

Qiushi Li, Long Chen, Xuewen Liu, Xidong Li, Yue Cao, Yang Bai, Fengjiao Qi

Article Affiliation:

Qiushi Li

Abstract:

Neuroinflammation has been known as an important pathogenetic contributor of Alzheimer's disease (AD). Pterostilbene is a natural compound which has neuroprotective activity. However, the effect of pterostilbene on amyloid-β (Aβ)-induced neuroinflammation has not been clarified. The aim of the present study was to investigate the effect of pterostilbene on Aβ-induced neuroinflammation in microglia. The results indicated that pterostilbene attenuated Aβ-induced cytotoxicity of BV-2 cells. Aβinduced NO production and iNOS mRNA and protein expression, while pterostilbene inhibited the induction. The expression and secretion levels of IL-6, IL-1β, and TNF-α were enhanced by Aβtreatment, whereas pterostilbene decreased them. Aβactivated NLRP3/caspase-1 inflammasome, which was inactivated by pterostilbene. In addition, the inhibitor of caspase-1 Z-YVAD-FMK attenuated the Aβ-induced neuroinflammation in BV-2 cells. In conclusion, pterostilbene attenuated the neuroinflammatory response induced by Aβin microglia through inhibiting the NLRP3/caspase-1 inflammasome pathway, indicating that pterostilbene might be an effective therapy for AD.

Study Type : In Vitro Study

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