Pterostilbene, a potential MCR-1 inhibitor that enhances the efficacy of polymyxin B. - GreenMedInfo Summary
Pterostilbene, a potential MCR-1 inhibitor that enhances the efficacy of polymyxin B.
Antimicrob Agents Chemother. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29339386
We characterized pterostilbene produced a synergistic effect with polymyxin B (FIC index=0.156 or 0.188) against MCR-producing Escherichia coli strains of both human and animal origin. The time-killing assays showed that either pterostilbene or polymyxin B failed to eradicate a mcr-1- and NDM-positive E. coli strain ZJ487, but the combination eliminated by 1-hour post-inoculation. The survival rate of mouse following the intraperitoneal infection significantly promoted from 0% to 60% in the group of combination therapy applied.