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Article Publish Status: FREE
Abstract Title:

Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats.

Abstract Source:

Neural Regen Res. 2012 Feb 25 ;7(6):421-5. PMID: 25774183

Abstract Author(s):

Haiqin Wu, Huqing Wang, Bei Zhang, Guilian Zhang, Ru Zhang, Lingfeng Zhang

Article Affiliation:

Haiqin Wu

Abstract:

In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha.

Study Type : Animal Study

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Sayer Ji
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