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Article Publish Status: FREE
Abstract Title:

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1.

Abstract Source:

J Int Med Res. 2021 Sep ;49(9):3000605211040762. PMID: 34590923

Abstract Author(s):

Jianxiu Duan, Mingyuan Yin, Yaqin Shao, Jiao Zheng, Shengdan Nie

Article Affiliation:

Jianxiu Duan

Abstract:

OBJECTIVE: Previous investigations indicated the anticancer activity of puerarin. The current study aimed to evaluate the effect and molecular mechanisms of puerarin in chemotherapy-resistant ovarian cancer cells.

METHODS: We examined the effects of puerarin in platinum-resistant epithelial ovarian cancer cellsand. We also analyzed the molecular mechanism underlying Wnt/β-catenin inhibition and sirtuin 1 (SIRT1) regulation following puerarin treatment.

RESULTS: Our study demonstrated that puerarin effectively inhibited cell growthandby increasing apoptosis in ovarian cancer cells. More importantly, puerarin sensitized cisplatin-resistant ovarian cancer cells to chemotherapy. Puerarin treatment decreased SIRT1 expression, which attenuated the nuclear accumulation ofβ-catenin to inhibit Wnt/β-catenin signaling. In addition, SIRT1 overexpression diminished the effects of puerarin treatment on cisplatin-resistant ovarian cancer cells. Further analysis supported SIRT1/β-catenin expression as a candidate biomarker for the disease progression of epithelial ovarian cancer.

CONCLUSIONS: Puerarin increased the apoptosis of platinum-resistant ovarian cancer cells. The mechanism is partly related to the downregulation of SIRT1 and subsequent inhibition of Wnt/β-catenin signaling.

Study Type : In Vitro Study

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