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Abstract Title:

Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy.

Abstract Source:

Biosci Biotechnol Biochem. 2021 Feb 24 ;85(3):621-625. PMID: 33624774

Abstract Author(s):

Guishuang Li, Hongming Rao, Weihong Xu

Article Affiliation:

Guishuang Li

Abstract:

Puerarin can protect chondrocytes, whereby ameliorating osteoarthritis. Puerarin also promotes autophagy. Autophagy maintains chondrocyte homeostasis. The role of autophagy in puerarin-protected chondrocytes is unknown. Puerarin promoted chondrocyte autophagy. Puerarin-protected chondrocytes were reversed by autophagy inhibitors and Beclin1 inhibitor. 3-MA or Beclin1 inhibitor in vivo reversed puerarin-ameliorated cartilage damage of osteoarthritis mice. Thus, puerarin can protect chondrocytes through Beclin1-dependent autophagy activation.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Chondroprotective : CK(1) : AC(1)

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Sayer Ji
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