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Article Publish Status: FREE
Abstract Title:

Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells.

Abstract Source:

Nutrients. 2021 Aug 10 ;13(8). Epub 2021 Aug 10. PMID: 34444911

Abstract Author(s):

Perrine Vermonden, Matthias Vancoppenolle, Emeline Dierge, Eric Mignolet, Géraldine Cuvelier, Bernard Knoops, Melissa Page, Cathy Debier, Olivier Feron, Yvan Larondelle

Article Affiliation:

Perrine Vermonden

Abstract:

Plant-derived conjugated linolenic acids (CLnA) have been widely studied for their preventive and therapeutic properties against diverse diseases such as cancer. In particular, punicic acid (PunA), a conjugated linolenic acid isomer (C18:3 c9t11c13) present at up to 83% in pomegranate seed oil, has been shown to exert anti-cancer effects, although the mechanism behind its cytotoxicity remains unclear. Ferroptosis, a cell death triggered by an overwhelming accumulation of lipid peroxides, has recently arisen as a potential mechanism underlying CLnA cytotoxicity. In the present study, we show that PunA is highly cytotoxic to HCT-116 colorectal and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. Moreover, our data indicate that PunA triggers ferroptosis in carcinoma cells. It induces significant lipid peroxidation and its effects are prevented by the addition of ferroptosis inhibitors. A combination with docosahexaenoic acid (DHA), a known polyunsaturated fatty acid with anticancer properties, synergistically increases PunA cytotoxicity. Our findings highlight the potential of using PunA as a ferroptosis-sensitizing phytochemical for the prevention and treatment of cancer.

Study Type : In Vitro Study

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