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Article Publish Status: FREE
Abstract Title:

Purple Sweet Potato Color Attenuates Kidney Damage by Blocking VEGFR2/ROS/NLRP3 Signaling in High-Fat Diet-Treated Mice.

Abstract Source:

Oxid Med Cell Longev. 2019 ;2019:5189819. Epub 2019 Jan 22. PMID: 30805082

Abstract Author(s):

Gui-Hong Zheng, Qun Shan, Jing-Jing Mu, Yong-Jian Wang, Zi-Feng Zhang, Shao-Hua Fan, Bin Hu, Meng-Qiu Li, Jun Xie, Ping Chen, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng

Article Affiliation:

Gui-Hong Zheng

Abstract:

Our preliminary data showed that VEGFR2 upregulation promoted renal ROS overproduction in high-fat diet- (HFD-) treated mice. Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism. Our results showed that VEGFR2 knockdown decreased ROS overproduction, blocked NLRP3-dependent inflammation, and alleviated kidney damage in HFD-treated mice. Treatment with-lipoic acid, a scavenger of ROS, lowered ROS overproduction and alleviated NLRP3-triggered kidney injury of HFD-treated mice. Collectively, the VEGFR2/ROS/NLRP3 signal is a critical therapeutic strategy for the kidney injury of HFD-treated mice. Purple sweet potato color (PSPC), a natural anthocyanin, can exert renal protection by inhibiting ROS in HFD-treated mice. Here, we provide a novel mechanism of PSPC against renal damage in HFD-treated mice by downregulating VEGFR2 expression.

Study Type : Animal Study

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