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Abstract Title:

The influences of purple sweet potato anthocyanin on the growth characteristics of human retinal pigment epithelial cells.

Abstract Source:

Food Nutr Res. 2015 ;59:27830. Epub 2015 Jun 11. PMID: 26070791

Abstract Author(s):

Min Sun, Xiaoling Lu, Lei Hao, Tao Wu, Huanjiao Zhao, Chao Wang

Article Affiliation:

Min Sun

Abstract:

BACKGROUND: Anthocyanins have been proven to be beneficial to the eyes. However, information is scarce about the effects of purple sweet potato (Ipomoea batatas, L.) anthocyanin (PSPA), a class of anthocyanins derived from purple sweet potato roots, on visual health.

OBJECTIVE: The aim of this study was to investigate whether PSPA could have influences on the growth characteristics (cellular morphology, survival, and proliferation) of human retinal pigment epithelial (RPE) cells, which perform essential functions for the visual process.

METHODS: The RPE cell line D407 was used in the present study. The cytotoxicity of PSPA was assessed by MTT assay. Then, cellular morphology, viability, cell cycle, Ki67expression, and PI3K/MAPK activation of RPE cells treated with PSPA were determined.

RESULTS: PSPA exhibited dose-dependent promotion of RPE cell proliferation at concentrations ranging from 10 to 1,000µg/ml. RPE cells treated with PSPA demonstrated a predominantly polygonal morphology in a mosaic arrangement, and colony-like cells displayed numerous short apical microvilli and typical ultrastructure. PSPA treatment also resulted in a better platform growing status, statistically higher viability, an increase in the S-phase, and more Ki67+ cells. However, neither pAkt nor pERK were detected in either group.

CONCLUSIONS: We found that PSPA maintained high cell viability, boosted DNA synthesis, and preserved a high percentage of continuously cycling cells to promote cell survival and division without changing cell morphology. This paper lays the foundation for further research about the damage-protective activities of PSPA on RPE cells or human vision.

Study Type : In Vitro Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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