Effects of Pycnogenol on Cisplatin Induced Optic Nerve Injury: an Experimental Study.
Cutan Ocul Toxicol. 2018 Jul 3:1-13. Epub 2018 Jul 3. PMID: 29969298
AIM: To determine the effects of Pycnogenol on cisplatin induced optic nerve damage.
MATERIAL AND METHOD: Totally 18 albino Wistar male rats were assigned into 3 groups, with 6 rats in each group as follows: healthy controls (HC group), only cisplatin (2. 5 mg/kg) administered group (CIS group), and Pycnogenol (40 mg/kg) + cisplatin (2. 5 mg/kg) administered group (PYC group). We analyzed the levels of Malondialdehyde (MDA) as a marker of lipid peroxidation and oxidative stress, total glutathione (tGSH) as a marker of antioxidant status, NuclearFactor- Kappa B (NF-KB) and Tumor necrosis factor alpha (TNF-a) as inflammatory markers, total oxidative status (TOS) and total antioxidant status (TAS) on eye tissue together with histopathological evaluation of optic nerve in an experimental model.
RESULTS: In CIS group MDA, TOS, TNF-a and NF-KB levels were statistically significantly higher (p < 0.001) than HC group while tGSH and TAS levels were significantly lower (p < 0.001). On the other hand, in PYC group MDA, TOS, TNF-a and NF-KB levels were statistically significantly lower (p < 0.001) than CIS group while tGSH and TAS levels were significantly higher (p < 0.001).
CONCLUSION: Pycnogenol pretreatment was highly effective in preventing augmentation of cisplatin induced oxidative stress and inflammation in eye tissue.