Abstract Title:

Pycnogenol® prevents oxidative stress and side effects in patients with hypothyroidism during levothyroxine treatment.

Abstract Source:

Minerva Endocrinol. 2019 Jun ;44(2):199-204. PMID: 31099529

Abstract Author(s):

Gianni Belcaro, Umberto Cornelli, Mark Dugall, Roberto Cotellese, Beatrice Feragalli, Maria R Cesarone

Article Affiliation:

Gianni Belcaro


BACKGROUND: In this study we aimed to evaluate the efficacy of Pycnogenol® supplementation in controlling oxidative stress levels and in reducing the frequency and severity of side effects of levothyroxine (LT4) treatment in patients who had recently started this therapy.

METHODS: The registry included 60 females affected by primary hypothyroidism with multi-nodular goiter. LT4 was administered at the dosage of 100μg/day.The registry study included only subjects under initial treatment, and followed up for a period of at least 30 days. A group took 150 mg Pycnogenol® daily and another served as control.

RESULTS: The global occurrence of symptoms during the 30-day period was significantly lower with the supplement (P<0.05).

CONCLUSIONS: Pycnogenol® may represent a useful tool to reduce LT4- related side effects in patients treated with hormone replacement therapy for hypothyroidism.

Study Type : Human Study

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