Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer's disease mice model. - GreenMedInfo Summary

INTRODUCTION: Alzheimer's disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death.

OBJECTIVE: To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model.

MATERIALS AND METHODS: Animals were injected intraperitoneally with quercetin every 48 hours during three months, and we conducted histological and biochemical studies.

RESULTS: We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased. GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates.

CONCLUSION: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer's disease mice.