Abstract Title:

Quercetin decreased alveolar bone loss and apoptosis in experimentally induced periodontitis model in Wistar rats.

Abstract Source:

Antiinflamm Antiallergy Agents Med Chem. 2020 Jan 23. Epub 2020 Jan 23. PMID: 31976849

Abstract Author(s):

Mehmet Murat Taskan, Fikret Gevrek

Article Affiliation:

Mehmet Murat Taskan


BACKGROUND: Quercetin is a flavonoid which has potent anti-inflammatory, antibacterial, and antioxidant effect. Purpose of this study was to evaluate effects of quercetin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats.

METHODS: Wistar rats were divided into four experimental groups: non-ligated control(C, n=8) group; periodontitis(P, n=8) group; ligature and low dose quercetin group(75 mg/kg/day quercetin, Q75 group, n=8); ligature and high dose quercetin group(150 mg/kg/day quercetin, Q150 group, n=8). Silk ligatures were placed at gingival margin of lower first molars of mandibular right quadrant. Study duration was 15 days, and animals were sacrificed end of this period. Changes in alveolar bone levels were clinically measured and tissues were immunohistochemically examined, matrix metalloproteinase 8(MMP 8), inducible nitric oxide synthase(iNOS), tissue inhibitor of metalloproteinase 1(TIMP 1), Cysteine-aspartic proteases 3(Caspase 3), and tartrate-resistant acid phosphatase(TRAP) positive osteoclast cells, osteoblast, and neutrophil counts were also determined.

RESULTS: Alveolar bone loss was highest in P group, and differences among P, Q75, and Q150 groups were significant. Both doses of quercetin decreased TRAP+ osteoclast cells and increased osteoblast cells. Inflammation in P group was also higher than those of C, Q75, and Q150 groups indicating anti-inflammatory effect of quercetin. iNOS, MMP-8, and caspase-3 levels were highest, and TIMP-1 expression was lowest in P group; differences were statistically significant.

CONCLUSION: Within limits of this study, it can be suggested that quercetin administration may reduce alveolar bone loss by increasing osteoblastic activity, decreasing osteoclastic activity, apoptosis, and inflammation in an experimental model of periodontitis.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.