Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Inhibition of gastric H+, K(+)-ATPase by quercetin.

Abstract Source:

J Enzyme Inhib. 1992;5(4):293-8. PMID: 1285250

Abstract Author(s):

S Murakami, M Muramatsu, S Otomo

Article Affiliation:

Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.

Abstract:

The effects of the naturally occurring flavonoid, quercetin, on gastric H+, K(+)-ATPase were investigated. Quercetin inhibited hog gastric H+, K(+)-ATPase and K(+)-stimulated p-nitrophenyl phosphatase (K(+)-pNPPase) activity in a dose dependent manner with IC50 values of 2.3 microM, and 6.0 microM respectively. The inhibition of H+, K(+)-ATPase by quercetin is competitive with ATP and is noncompetitive with K+. The steady-state phosphorylation level of the enzyme was also dose-dependently reduced by quercetin with an IC50 value of 4.5 microM. These results suggest that quercetin reduces the phosphorylated enzyme level by competition with ATP, and thereby inhibits the H+, K(+)-ATPase activity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Proton Pump Inhibitor : CK(36) : AC(13)

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.