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Abstract Title:

The effect of local breast radiotherapy on circulating CD34(+) cells.

Abstract Source:

Radiother Oncol. 2011 Aug ;100(2):304-7. Epub 2011 Feb 11. PMID: 21316784

Abstract Author(s):

Nehad M Alajez, Wei Wang, Debashis Biswas, Amy Teh, Robert Sutherland, Melania Pintilie, Mark Minden, Hans Messner, Anthony Fyles, Mary Gospodarowicz, Armand Keating, Fei-Fei Liu

Article Affiliation:

Ontario Cancer Institute, Toronto, Canada.

Abstract:

The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Radiotherapy : CK(415) : AC(73)
Adverse Pharmacological Actions : Immunotoxic : CK(338) : AC(66)

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Sayer Ji
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