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Abstract Title:

Vitamin A and immunity to viral, bacterial and protozoan infections.

Abstract Source:

Proc Nutr Soc. 1999 Aug ;58(3):719-27. PMID: 10604208

Abstract Author(s):

R D Semba

Article Affiliation:

R D Semba

Abstract:

Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrhoeal disease, measles-related pneumonia, human immunodeficiency virus infection and malaria. Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved.

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Sayer Ji
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