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Abstract Title:

An antifungal peptide from red lentil seeds.

Abstract Source:

Peptides. 2007 Mar;28(3):547-52. Epub 2006 Nov 22. PMID: 17123664

Abstract Author(s):

H X Wang, T B Ng

Article Affiliation:

State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing, China. hxwang@cau.edu.cn

Abstract:

An antifungal peptide, with a molecular mass of 11 kDa, was isolated from dry seeds of the red lentil (Lens culinaris) using a procedure that involved four chromatographic steps. The antifungal peptide was unadsorbed on DEAE-cellulose, and adsorbed on Affi-gel blue gel and S-Sepharose. The final chromatographic step involved gel filtration by fast protein liquid chromatography on Superdex 75. The antifungal peptide inhibited mycelial growth in Mycosphaerella arachidicola with an IC50 of 36 microM. It also exhibited antifungal activity against Fusarium oxysporum, but there was no inhibitory activity toward tumor cell lines and human immunodeficiency virus type 1 reverse transcriptase (RT).

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(403) : AC(237)

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Sayer Ji
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