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Abstract Title:

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats.

Abstract Source:

J Cell Physiol. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31898818

Abstract Author(s):

Sara Damiano, Valentina Iovane, Caterina Squillacioti, Nicola Mirabella, Francesco Prisco, Andrea Ariano, Margherita Amenta, Antonio Giordano, Salvatore Florio, Roberto Ciarcia

Article Affiliation:

Sara Damiano

Abstract:

In this work, we investigated the effects of red orange and lemon extract (RLE) on ochratoxin A (OTA)-induced nephrotoxicity. In particular, we analyzed the change in renal function and oxidative stress in Sprague-Dawley rats treated with OTA (0.5 mg/kg body weight, b.w.) and with RLE (90 mg/kg b.w.) by oral administration. After OTA treatment, we found alterations of biochemical and oxidative stress parameters in the kidney, related to a severe decrease of glomerular filtration rate. The RLE treatment normalized the activity of antioxidant enzymes and prevented the glomerular hyperfiltration. Histopathological examinations revealed glomerular damages and kidney cortex fibrosis in OTA-rats, while we observed less severe fibrosis in OTA plus RLE group. Then, we demonstrated that oxidative stress could be the cause of OTA renal injury and that RLE reduces this effect.

Study Type : Animal Study

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