Abstract Title:

Regression of rat primary mammary tumors following dietary d-limonene.

Abstract Source:

J Natl Cancer Inst. 1986 Feb ;76(2):323-5. PMID: 3080636

Abstract Author(s):

J A Elegbede, C E Elson, M A Tanner, A Qureshi, M N Gould

Article Affiliation:

J A Elegbede


The effects of d-limonene on rat mammary tumors were investigated. Following the appearance of mammary tumors induced by 7,12-dimethylbenz[a]anthracene in female (W/Fu X F344)F2 rats, animals were assigned to pairs in which 1 rat was fed a diet containing 10% d-limonene and the other was pair fed an isocaloric diet containing 10% cellulose. There was a highly significant increase in the regression of the first tumors in the rats fed d-limonene. In addition, d-limonene given at this time inhibited the formation of subsequent multiple tumors in these rats.

Study Type : Animal Study

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