Regression of rat primary mammary tumors following dietary d-limonene. - GreenMedInfo Summary
Regression of rat primary mammary tumors following dietary d-limonene.
J Natl Cancer Inst. 1986 Feb ;76(2):323-5. PMID: 3080636
J A Elegbede
The effects of d-limonene on rat mammary tumors were investigated. Following the appearance of mammary tumors induced by 7,12-dimethylbenz[a]anthracene in female (W/Fu X F344)F2 rats, animals were assigned to pairs in which 1 rat was fed a diet containing 10% d-limonene and the other was pair fed an isocaloric diet containing 10% cellulose. There was a highly significant increase in the regression of the first tumors in the rats fed d-limonene. In addition, d-limonene given at this time inhibited the formation of subsequent multiple tumors in these rats.