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Abstract Title:

Antioxidants from black and green tea: from dietary modulation of oxidative stress to pharmacological mechanisms.

Abstract Source:

Br J Pharmacol. 2016 Oct 16. Epub 2016 Aug 16. PMID: 27747873

Abstract Author(s):

Ilaria Peluso, Mauro Serafini

Article Affiliation:

Ilaria Peluso

Abstract:

Consumption of Tea (Camellia Sinensis) has been correlated with low incidence of chronic pathologies, such as cardiovascular diseases and cancers, in which oxidative stress is deeply involved. Tea catechins and theaflavins are, respectively, the bioactive phytochemicals responsible for the antioxidant activity of Green Tea (GT) and Black Tea (BT). Apart from the redox properties, tea catechins and theaflavins could have also pharmacological activities, such as lowering effects on glucose, lipid and uric acid (UA). These activities are mediated by pharmacological mechanisms such as enzymatic inhibition and interaction with transporters. Epigallocatechin gallate is the most active compound in the inhibition of enzymes involved in cholesterol and UA metabolism (hydroxy-3-methyl-glutaryl-CoA reductase: IC50 10(-8) M; xanthine oxidase: IC50 10(-7) M) and of glucose transporters (IC50 10(-7) M). The structural features of catechins that significantly contribute to their pharmacological effect are the presence/absence of the galloyl moiety and the number and positions of the hydroxyl groups on the rings. On the other hand, although the inhibitory effect onα-glucosidase, maltase, amylase and lipase, multidrug resistance 1, Organic Anion-Transporters and Proton coupled folate transport occurs at higher concentrations (IC50 10(-6) M -10(-5) M) compared to circulating levels, it must be taken into account that these effects could be relevant in the gut.In conclusion, despite the urgent need for further research in human, the regular consumption of moderate quantity of GT and BT can efficiently modulate antioxidant capacity of body fluids, mainly in people under oxidative stress, and could improve the metabolism of glucose, lipid and UA. This article is protected by copyright. All rights reserved.

Study Type : In Vitro Study

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