Abstract Title:

Yellow fever vaccine: an updated assessment of advanced age as a risk factor for serious adverse events.

Abstract Source:

Vaccine. 2005 May 9 ;23(25):3256-63. PMID: 15837230

Abstract Author(s):

Alena Y Khromava, Rachel Barwick Eidex, Leisa H Weld, Katrin S Kohl, Robert D Bradshaw, Robert T Chen, Martin S Cetron,

Article Affiliation:

Alena Y Khromava


Since 1996, the scientific community has become aware of 14 reports of yellow fever vaccine (YEL)-associated viscerotropic disease (YEL-AVD) cases and four reports of YEL-associated neurotropic disease (YEL-AND) worldwide, changing our understanding of the risks of the vaccine. Based on 722 adverse event reports after YEL submitted to the U.S. Vaccine Adverse Event Reporting System in 1990-2002, we updated the estimates of the age-adjusted reporting rates of serious adverse events, YEL-AVD and YEL-AND. We found that the reporting rates of serious adverse events were significantly higher among vaccinees aged>or =60 years than among those 19-29 years of age (reporting rate ratio = 5.9, 95% CI 1.6-22.2). Yellow fever is a serious and potentially fatal disease. For elderly travelers, the risk for severe illness and death due to yellow fever infection should be balanced against the risk of a serious adverse event due to YEL.

Study Type : Human Study

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