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Article Publish Status: FREE
Abstract Title:

Reprogramming the Epigenome With Vitamin C.

Abstract Source:

Front Cell Dev Biol. 2019 ;7:128. Epub 2019 Jul 16. PMID: 31380368

Abstract Author(s):

Taylor Lee Chong, Emily L Ahearn, Luisa Cimmino

Article Affiliation:

Taylor Lee Chong

Abstract:

The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin C plays a pivotal role in remodeling the epigenome by enhancing the activity of Jumonji-C domain-containing histone demethylases (JHDMs) and the ten-eleven translocation (TET) proteins. By maintaining differentiation plasticity in culture, vitamin C also improves the quality of tissue specific stem cells derived from iPSCs that are highly sought after for use in regenerative medicine. The ability of vitamin C to potentiate the activity of histone and DNA demethylating enzymes also has clinical application in the treatment of cancer. Vitamin C deficiency has been widely reported in cancer patients and has recently been shown to accelerate cancer progression in disease models. Therapies involving high-dose vitamin C administration are currently gaining traction in the treatment of epigenetic dysregulation, by targeting aberrant histone and DNA methylation patterns associated with cancer progression.

Study Type : Review

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Sayer Ji
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