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Article Publish Status: FREE
Abstract Title:

The Protective Effect of Magnolol in Osteoarthritis:andStudies.

Abstract Source:

Front Pharmacol. 2019 ;10:393. Epub 2019 Apr 16. PMID: 31040782

Abstract Author(s):

Zhi-Chao Hu, Zu-Cheng Luo, Bing-Jie Jiang, Xin Fu, Jiang-Wei Xuan, Xiao-Bin Li, Yu-Jie Bian, Wen-Fei Ni, Ji-Xin Xue

Article Affiliation:

Zhi-Chao Hu

Abstract:

Osteoarthritis (OA), defined as a long-term progressive joint disease, is characterized by cartilage impairment and erosion. In recent decades, magnolol, as a type of lignin extracted from, has been proved to play a potent anti-inflammatory role in various diseases. The current research sought to examine the latent mechanism of magnolol and its protective role in alleviating the progress of OAas well asexperimentations., the over-production of Nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6), induced by interleukin-1 beta (IL-1β), were all inhibited notably by magnolol in a concentration-dependent manner. Moreover, magnolol could also downregulate the expression of metalloproteinase 13 (MMP13) and thrombospondin motifs 5 (ADAMTS5). All these changes ultimately led to the deterioration of the extracellular matrix (ECM) induced by IL-1β. Mechanistically, magnolol suppressed the activation of PI3K/Akt/NF-κB pathway. Furthermore, a powerful binding capacity between magnolol and PI3K was also revealed in our molecular docking research. In addition, magnolol-induced protective effects in OA development were also detected in a mouse model. In summary, this research suggested that magnolol possessed a new therapeutic potential for the development of OA.

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