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Article Publish Status: FREE
Abstract Title:

Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention.

Abstract Source:

Cannabis Cannabinoid Res. 2017 ;2(1):259-264. Epub 2017 Oct 1. PMID: 29098188

Abstract Author(s):

Eugene L Scharf

Article Affiliation:

Eugene L Scharf

Abstract:

Introduction: The endocannabinoid system (ECS) regulates functions throughout human physiology, including neuropsychiatric, cardiovascular, autonomic, metabolic, and inflammatory states. The complex cellular interactions regulated by the ECS suggest a potential for vascular disease and stroke prevention by augmenting central nervous and immune cell endocannabinoid signaling. Discussion: The endocannabinoid N-arachidonoylethanolamine (anandamide) plays a central role in augmenting these processes in cerebrovascular and neurometabolic disease. Furthermore, cannabidiol (CBD), a nonpsychoactive constituent of Cannabis, is an immediate therapeutic candidate both for potentiating endocannabinoid signaling and for acting at multiple pharmacological targets. Conclusion: This speculative synthesis explores the current state of knowledge of the ECS and suggests CBD as a therapeutic candidate for stroke prevention by exerting favorable augmentation of the homeostatic effects of the ECS and, in turn, improving the metabolic syndrome, while simultaneously stalling the development of atherosclerosis.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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