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Article Publish Status: FREE
Abstract Title:

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish.

Abstract Source:

Front Pharmacol. 2020 ;11:607797. Epub 2021 Jan 11. PMID: 33505312

Abstract Author(s):

Pallavi Sharma, Savita Kumari, Jatin Sharma, Rituraj Purohit, Damanpreet Singh

Article Affiliation:

Pallavi Sharma

Abstract:

Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside) is aβ-7-rutinoside of hesperetin (4'-methoxy-3',5,7-trihydroxyflavanone), abundantly found in citrus fruits and known to interact with various cellular pathways to show a variety of pharmacological effects. The present study was envisaged to understand the anticonvulsant effect of hesperidin in a zebrafish model of pentylenetetrazole (PTZ)-induced convulsions, with the support ofdocking. Healthy zebrafish larvae were preincubated with hesperidin (1, 5, and 10 µM) for 1 h, before PTZ exposure. Hesperidin treatment significantly increased the seizure latency and minimized PTZ-induced hyperactive responses. A significant reduction inexpression further supported the suppression of neuronal excitation following hesperidin incubation in the larvae exposed to PTZ. The treatment also modulated larvalexpression and reduced the expression of. The results ofstudies were further supported bydocking analysis, which showed the affinity of hesperidin for the N-methyl-d-aspartate receptor, the gamma-aminobutyric acid receptor, Interleukin 10 and the TrkB receptor of brain-derived neurotrophic factor. The results concluded that hesperidin suppresses PTZ-mediated seizure in zebrafish larvae through interaction with the central CREB-BDNF pathway.

Study Type : Animal Study

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