Abstract Title:

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ) toxicity and aggregation.

Abstract Source:

Neurochem Int. 2019 Jan 9 ;124:215-224. Epub 2019 Jan 9. PMID: 30639263

Abstract Author(s):

Mousa Alghazwi, Scott Smid, Ian Musgrave, Wei Zhang

Article Affiliation:

Mousa Alghazwi


Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβfibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. The results demonstrated that both astaxanthin and fucoxanthin exhibited multi-neuroprotective effects favouring fucoxanthin over astaxanthin supporting neuroprotective roles of marine-derived carotenoids as potential novel dementia prevention or therapeutic strategies.

Study Type : In Vitro Study

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