Abstract Title:

In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei.

Abstract Source:

Mycopathologia. 2019 Feb 25. Epub 2019 Feb 25. PMID: 30805832

Abstract Author(s):

Hong Luo, Kai-Su Pan, Xiao-Lu Luo, Dong-Yan Zheng, Alex Andrianopoulos, Le-Min Wen, Yan-Qing Zheng, Jing Guo, Chun-Yang Huang, Xiu-Ying Li, Rong Hu, Yu-Jiao Li, Tian-Min Li, Justin Joseph, Cun-Wei Cao, Gang Liang

Article Affiliation:

Hong Luo


Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52.38%), itraconazole (66.67%), voriconazole (71.43%), amphotericin B (71.43%) or caspofungin (52.38%) of T. marneffei strains, respectively. Time-kill curves confirmed the synergistic interaction, and no antagonistic was observed in all of the combinations. In conclusion, berberine could enhance the efficacy of conventional antifungal agents against the yeast form of T. marneffei in vitro. The results indicated berberine might have a potential role in combination therapy for talaromycosis.

Study Type : In Vitro Study

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