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Abstract Title:

Magnolia Officinalis Reduces Inflammation And Damage Induced By Recurrent Status Epilepticus In Immature Rats

Abstract Source:

Curr Pharm Des. 2020 03 20. Epub 2020 Mar 20. PMID: 32196444

Abstract Author(s):

Angélica Vega-García, Luisa Rocha, Rosalinda Guevara-Guzmán, Christian Guerra-Araiza, Iris Feria-Romero, Juan Manuel Gallardo, Teresa Neri-Gomez, José Eduardo Suárez-Santiago, Sandra Orozco-Suarez

Article Affiliation:

Angélica Vega-García

Abstract:

BACKGROUND: Neuroinflammation induced in response to damage caused by status epilepticus (SE) activates the interleukin (IL)1-β pathway and proinflammatory proteins that increase vulnerability to the development of spontaneous seizure activity and/or epilepsy.

OBJECTIVES: To assess the short-term anti-inflammatory and neuroprotective effects of Magnolia officinalis (MO) on recurrent SE in immature rats.

METHODS: Sprague-Dawley rats at PN day 10 were used; n = 60 rats were divided into two control groups, SHAM and KA, and two experimental groups, MO (KA-MO) and Celecoxib (KA-Clbx). The anti-inflammatory effect of a single dose of MO was evaluated at 6 and 24 hr by Western blotting and on day 30 PN via a subchronic administration of MO to assess neuronal preservation and hippocampal gliosis by immunohistochemistry for NeunN and GFAP, respectively.

RESULTS: KA-MO caused a decrease in the expression of IL1-β and Cox-2 at 6 and 24 h post treatment, a reduction in iNOS synthase at 6 and 24 hr post treatment and reduced neuronal loss and gliosis at postnatal day 30, similar to Clbx.

CONCLUSION: The results indicating that Magnolia officinalis is an alternative preventive treatment for early stages of epileptogenesis are encouraging.

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