Article Publish Status: FREE
Abstract Title:

Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats.

Abstract Source:

J Ayurveda Integr Med. 2018 Oct 10. Epub 2018 Oct 10. PMID: 30316725

Abstract Author(s):

Rathinasamy Baskaran, Lohanathan Bharathi Priya, V Sathish Kumar, Viswanadha Vijaya Padma

Article Affiliation:

Rathinasamy Baskaran


BACKGROUND: Cadmium (Cd) pollution is of serious concern due to its toxic effects in both humans and animals. The study investigates the protective effect of Tinospora cordifolia stem methanolic extract (TCME) on Cd induced hepatotoxicity.

OBJECTIVE: The aim of the study was to explore the hepatoprotective effects of T. cordifolia extract.

MATERIALS AND METHODS: Rats were administered orally with Cd (5 mg/kg) and TCME (100 mg/kg) for 28 days. At the end of the treatment period, serum and liver tissues homogenates were subjected to biochemical analysis.

RESULTS: Cd treated rats showed increased activities of the serum marker enzymes of liver damage such as AST and ALT along with increased levels of LPO and protein carbonyl content in liver tissues. Cd treatment also leads to decreased activities of endogenous antioxidants (SOD, CAT, GSH, GPx and GST), membrane ATPases (NaKATPase, CaATPase and MgKATPase) and the tissue glycoprotein levels (hexose, fucose, hexosamine and sialic acid). Histological analysis revealed vacuolar degeneration of hepatocytes with focal necrosis upon Cd administration. TCME co-treatment restored the biochemical and histological alterations caused by Cd intoxication to near normal levels.

CONCLUSION: The results of the present investigation reveal the hepatoprotective nature of T.cordifolia against Cd induced hepatotoxicity.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.