Article Publish Status: FREE
Abstract Title:

p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.

Abstract Source:

FEBS Lett. 2005 Sep 12 ;579(22):5084-8. PMID: 16139274

Abstract Author(s):

Blanca Herrera, Arkaitz Carracedo, María Diez-Zaera, Manuel Guzmán, Guillermo Velasco

Article Affiliation:

Blanca Herrera

Abstract:

Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.

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