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Abstract Title:

Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.

Abstract Source:

Toxicol In Vitro. 2019 Feb ;54:338-344. Epub 2018 Oct 30. PMID: 30385350

Abstract Author(s):

Dong-Jun Fu, Ping Li, Jian Song, Sai-Yang Zhang, Han-Zhong Xie

Article Affiliation:

Dong-Jun Fu

Abstract:

Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, the toxicity remained on long-term low-dose condition.

Study Type : In Vitro Study
Additional Links
Problem Substances : Pesticides : CK(827) : AC(95)
Adverse Pharmacological Actions : Neurotoxic : CK(1458) : AC(323)

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