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Article Publish Status: FREE
Abstract Title:

The Effects ofJuice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk.

Abstract Source:

Nutrients. 2020 May 20 ;12(5). Epub 2020 May 20. PMID: 32443695

Abstract Author(s):

Ljiljana Stojković, Ivan Jovanović, Maja Zivković, Manja Zec, Tamara Djurić, Ivan Zivotić, Jovana Kuveljić, Ana Kolaković, Ivana Kolić, Ana Djordjević, Marija Glibetić, Dragan Alavantić, Aleksandra Stanković

Article Affiliation:

Ljiljana Stojković

Abstract:

Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease. The aim of this three-arm, crossover, randomized, double-blind, placebo-controlled intervention study was to examine the impact ofjuice (AMJ), high-polyphenol (AMJ treatment, 1.17 g/100 mL polyphenols) and low-polyphenol (dAMJ treatment, 0.29 g/100 mL polyphenols) dose, on the transcriptome in peripheral blood mononuclear cells (PBMC) of 19 subjects at cardiovascular risk. Transcriptome data were obtained by microarray. Bioinformatic functional annotation analysis was performed on both the whole transcriptome datasets and the differentially expressed genes (DEGs). Expression of selected DEGs was validated by RT-qPCR. Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles, with the most pronounced and specific effect noticed for AMJ in the last treatment period (TP3) of the trial. Between the high-dose and low-dose treatments in TP3, there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways, which primarily included immunomodulation and regulation of cell proliferation/death. Increased expression of,,,,, andin TP3 was confirmed by RT-qPCR. The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk.

Study Type : Human Study

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