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Abstract Title:

Multigenerational Effects of Maternal Cigarette Smoke Exposure during Pregnancy on Sperm Counts of F1 and F2 Male Offspring.

Abstract Source:

Reprod Toxicol. 2018 Apr 21. Epub 2018 Apr 21. PMID: 29689290

Abstract Author(s):

Hye Jeong Lee, Na Young Choi, Yo Seph Park, Seung-Won Lee, Jin Seok Bang, Yukyeong Lee, Jae-Sung Ryu, Seong-Jin Choi, Sang-Hyub Lee, Gwang Soo Kim, Hyun Woo Chung, Kisung Ko, Kyuhong Lee, Kinarm Ko

Article Affiliation:

Hye Jeong Lee

Abstract:

Animal models and human studies showed that in utero cigarette smoke exposure decreases sperm counts of offspring. This study used a mouse model to investigate the effects of maternal exposure to cigarette smoke on reproductive systems in F1 and F2 male offspring. Female ICR mice were exposed either to clean air or to cigarette smoke during pregnancy at the post-implantation stage. Epididymal sperm counts were decreased in a cigarette smoke dose-dependent manner in F1 (by 40-60%) and F2 males (by 23-40%) at postnatal day 56. In F1, the seminiferous epithelium heights were lower in the cigarette smoke-exposed groups than in the control group, and these effects were sustained in F2 males. Results suggest that maternal cigarette smoke exposure during pregnancy can have a multigenerational adverse effect on sperm counts in male offspring, which is mediated through in utero exposure of fetal germ cells to cigarette smoke.

Study Type : Animal Study

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