Abstract Title:

Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression.

Abstract Source:

Arch Pharm Res. 2015 Oct 1. Epub 2015 Oct 1. PMID: 26428673

Abstract Author(s):

Seung Hwa Kim, Kyung Hwa Cho, Yu Na Kim, Bo Young Jeong, Chang Gyo Park, Gang Min Hur, Hoi Young Lee

Article Affiliation:

Seung Hwa Kim

Abstract:

Stress hormone norepinephrine (NE) has been associated with acquisition of cancer progression, and naturally occurring phytoalexin resveratrol (REV) has been known to suppress cancer growth and progression. In the present study, we determine the effect of REV on NE-induced ovarian cancer invasiveness. Pretreatment of REV significantly inhibited NE-induced ovarian cancer cell epithelial-to-mesenchymal transition with concomitant recovery of E-cadherin expression. In addition, our data showed that REV downregulates NE-induced human telomerase reverse transcriptase (hTERT) expression through inhibiting Src phosphorylation and HIF-1α expression. Further, REV reduced NE-induced Slug expression and subsequent ovarian cancer invasion. More importantly, combined treatment of REV with a pharmacological inhibitor of beta adrenergic receptor significantly attenuated NE-induced ovarian cancer invasion compared to single treatment. Therefore, we demonstrate interference of a Src and HIF-1α/hTERT/Slug signaling cascade by REV, providing potential therapeutic targets and inhibition of ovarian cancer.

Study Type : In Vitro Study

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