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Abstract Title:

GADD45α and annexin A1 are involved in the apoptosis of HL-60 induced by resveratrol.

Abstract Source:

Phytomedicine. 2011 Jan 28. Epub 2011 Jan 28. PMID: 21277758

Abstract Author(s):

Guanwu Li, Shunhua He, Lijun Chang, Hong Lu, Hongwei Zhang, Hao Zhang, Jenfu Chiu

Article Affiliation:

Open Laboratory for Tumor Molecular Biology/Department of Biochemistry, Shantou University Medical College, Shantou, China.

Abstract:

Resveratrol (3,4',5-trihydroxy-trans-stilbene), one of secondary metabolites of low molecular weight present in plant, has various important biological effects. It can induce apoptosis in human leukemia cell types in vitro, although the mechanism is not fully understood. In the present study, we demonstrated reduced viability and DNA synthesis, as well as increased proportion of the subdiploid cell population, in HL-60 cells as determined by cell cycle analysis with resveratrol. Resveratrol treatment resulted in a gradual time-dependent decrease in the expression of anti-apoptotic Bcl-2 and increase in that of Bax, annexin A1, growth arrest- and DNA damage-induced gene 45α (GADD45α), and cleaved caspase-3. In addition, resveratrol markedly increased caspase-3 activity in cells. Our results suggest that resveratrol could inhibit the proliferation and induce apoptosis of HL-60 cells through a GADD45α and annexin A1/caspase-3 pathway.

Study Type : In Vitro Study

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Sayer Ji
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