Abstract Title:

Actions of redox-active compound resveratrol under hydrogen peroxide insult in C6 astroglial cells.

Abstract Source:

Toxicol In Vitro. 2010 Apr;24(3):916-20. Epub 2009 Nov 27. PMID: 19945524

Abstract Author(s):

André Quincozes-Santos, Ana Cristina Andreazza, Carlos-Alberto Gonçalves, Carmem Gottfried

Article Affiliation:

Research Group in Neuroglial Plasticity, Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. andrequincozes@yahoo.com.br


The mechanisms by which resveratrol (3,5,4'-trihydroxy-stilbene) imparts neural effects is not well understood. We previously demonstrated that, depending upon the concentration of resveratrol and the cell type, this compound exerts anti-or pro-oxidant effects. In the present study, we investigated the effects of resveratrol on H(2)O(2)-mediated genotoxicity in C6 astroglial cells (I - 1mM H(2)O(2)/30 min or II - 0.1mM H(2)O(2)/6h), evaluated by micronucleus assay, lipid peroxidation (TBARS) and membrane integrity. H(2)O(2) increased micronuclei to 1.5 (I) and 1.7-fold (II), compared to control cells. This DNA damage was prevented (I) or partially prevented (II) by resveratrol. Oxidative insult also increased TBARS, 52% in I and 38% in II, P<0.05. These effects were prevented by resveratrol in I and increased in II (70% of increase). Present data contribute to the understanding of resveratrol effects under oxidative stress damage.

Study Type : In Vitro Study

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