Resveratrol induces DNA damage and cell cycle arrest in glioblastoma cells. - GreenMedInfo Summary
Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction.
Cancer Lett. 2010 Sep 28;295(2):167-72. Epub 2010 Mar 20. PMID: 20304553
Dipartimento di Biologia, Università degli Studi Roma Tre, Roma, Italy.
Resveratrol, a stilbene found in grapes and wine, is one of the most interesting natural compound due to its role exerted in cancer prevention and therapy. In particular, resveratrol is able to delay cell cycle progression and to induce apoptotic death in several cell lines. Here we report that resveratrol treatment of human glioblastoma cells induces a delay in cell cycle progression during S phase associated with an increase in histone H2AX phosphorylation. Furthermore, with an in vitro assay of topoisomerase IIalpha catalytic activity we show that resveratrol is able to inhibit the ability of recombinant human TOPO IIalpha to decatenate kDNA, so that it could be considered a TOPO II poison.