Abstract Title:

Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-kappaB activation.

Abstract Source:

Arch Pharm Res. 2009 Apr;32(4):583-91. Epub 2009 Apr 29. PMID: 19407977

Abstract Author(s):

Hyun-Joo Park, Seong-Kyoon Jeong, Su-Ryun Kim, Soo-Kyung Bae, Woo-Sik Kim, Seong-Deok Jin, Tae Hyeon Koo, Hye-Ock Jang, Il Yun, Kyu-Won Kim, Moon-Kyoung Bae

Abstract:

P. gingivalis is a major pathogen that is involved in the onset and progression of periodontal disease. This study investigated the effect of resveratrol, a naturally occurring polyphenol, on P. gingivalis LPS-accelerated vascular inflammation, a key step in the progression of periodontitis. Resveratrol significantly inhibited the P. gingivalis LPS-induced adhesion of leukocytes to endothelial cells and to the aortic endothelium by down-regulating the cell adhesion molecules, ICAM-1 and VCAM-1. Moreover, the inhibition of the P. gingivalis LPS-induced cell adhesion molecules by resveratrol was mainly mediated by nuclear factor-kappaB (NF-kappaB). Resveratrol suppressed P. gingivalis LPS-stimulated IkappaBalpha phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB in HMECs. Overall, these findings suggest that resveratrol significantly attenuates the P. gingivalis LPS-induced monocyte adhesion to the endothelium by suppressing the expression of the NF-kappaB-dependent cell adhesion molecules, suggesting its therapeutic role in periodontal pathogen-induced vascular inflammation.

Study Type : In Vitro Study

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