Abstract Title:

Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth.

Abstract Source:

Colloids Surf B Biointerfaces. 2016 Apr 2 ;144:65-72. Epub 2016 Apr 2. PMID: 27070053

Abstract Author(s):

Bruna Carletto, Juliana Berton, Tamara Nascimento Ferreira, Luciana Facco Dalmolin, Katia Sabrina Paludo, Rubiana Mara Mainardes, Paulo Vitor Farago, Giovani Marino Favero

Article Affiliation:

Bruna Carletto


In this study, resveratrol-loaded nanocapsules were developed and its antitumor activity tested on a melanoma mice model. These nanocapsules were spherically-shaped and presented suitable size, negative charge and high encapsulation efficiency for their use as a modified-release system of resveratrol. Nanoencapsulation leads to the drug amorphization. Resveratrol-loaded nanoparticles reduced cell viability of murine melanoma cells. There was a decrease in tumor volume, an increase in the necrotic area and inflammatory infiltrate of melanoma when resveratrol-loaded nanocapsules were compared to free resveratrol in treated mice. Nanoencapsulation of resveratrol also prevented metastasis and pulmonary hemorrhage. This modified-release technology containing resveratrol can be used as a feasible approach in order to inhibit murine melanoma tumor growth.

Study Type : Animal Study

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