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Abstract Title:

Resveratrol caused apoptosis in QGY-7701 cells.

Abstract Source:

Eur Rev Med Pharmacol Sci. 2015 Sep ;19(17):3303-8. PMID: 26400538

Abstract Author(s):

J-P Li

Article Affiliation:

J-P Li

Abstract:

OBJECTIVE: This study aims to evaluate the cytotoxicity of resveratrol in QGY-7701 cells using a cell viability assay and determine genetic damages after 24-h exposure to concentrations of 6, 12, and 24µmol·L-1.

MATERIALS AND METHODS: Cell viability and genetic damages were determined using a WST-1 assay and Hoechst 33342 staining with single cell gel electrophoresis (SCGE), respectively. Reactive oxygen species (ROS) levels were also determined.

RESULTS: The results demonstrated that resveratrol inhibited QGY-7701 cell growth and decreased their viability in a dose-dependent manner. Furthermore, resveratrol caused nuclear morphological changes and DNA damage, promoted ROS levels, and induced cell apoptosis.

CONCLUSIONS: These results suggest that resveratrol may induce QGY-7701 cell apoptosis by triggering excessive ROS generation and DNA damage.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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Sayer Ji
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