Interaction of transresveratrol with plasma lipoproteins.
Biochem Pharmacol. 1998 Mar 15;55(6):811-6. PMID: 9586953
Laboratoire de Nutrition et Sécurité Alimentaire, CRJ-INRA, Jouy-en-Josas, France.
Resveratrol (3,4',5-trihydroxystilbene) is a phytoalexin present in some red wines. Like other phenolic substances, this compound is assumed to protect against atherosclerosis by reducing the peroxidative degradation of low-density lipoproteins (LDL). The in vitro efficiency of resveratrol was found to be mainly due to its capacity to chelate copper, although it also scavenges free radicals. In this study, we examined the ability of the compound to associate with lipoproteins in vitro. Trans-resveratrol added to plasma was distributed between subsequently isolated lipoproteins with a linear dose-response curve. The concentrations as expressed on a protein basis increased with the order of their lipid content: high-density lipoproteins (HDL)