Abstract Title:

Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts.

Abstract Source:

J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):9-18. Epub 2010 Sep 24. PMID: 20884849

Abstract Author(s):

Lisa Giovannelli, Vanessa Pitozzi, Michela Jacomelli, Nadia Mulinacci, Anna Laurenzana, Piero Dolara, Alessandra Mocali

Article Affiliation:

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.


Recent research has focused on natural compounds possibly endowed with antiaging effects. Resveratrol is a stilbene compound produced by different plants with many biologic activities, including an antiaging effect, which has been demonstrated both in vitro in eukaryotic cells and in vivo in mice. We studied the effect of resveratrol on cultured human MRC5 fibroblasts, a widely used in vitro model in aging studies. The chronic treatment of MRC5 cells until senescence with 5μM resveratrol induced a small increase in the total number of replications completed by the cultures at senescence, showed protective effects against DNA oxidative damage, and reduced senescence-associated increases in nuclear size and DNA content. A reduction in the levels of acetylated forms ofH3 and H4 histones and p53 protein was also found.

Study Type : In Vitro Study

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