Resveratrol is a remarkable inhibitor of ribonucleotide reductase. - GreenMedInfo Summary
Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
FEBS Lett. 1998 Jan 16;421(3):277-9. PMID: 9468322
Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France. Fontecav@cbcrb.ceng.cea.fr
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.