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Abstract Title:

Structure-dependent inhibition of gelatinases by dietary antioxidants in rat astrocytes and sera of multiple sclerosis patients.

Abstract Source:

Neurochem Res. 2011 Mar;36(3):518-27. Epub 2011 Jan 5. PMID: 21207142

Abstract Author(s):

Grazia Maria Liuzzi, Tiziana Latronico, Maria Teresa Branà, Pasqua Gramegna, Maria Gabriella Coniglio, Rocco Rossano, Marilena Larocca, Paolo Riccio

Article Affiliation:

Department of Biochemistry and Molecular Biology, "Ernesto Quagliariello", University of Bari, Via Orabona 4, 70126, Bari, Italy, m.g.liuzzi@biologia.uniba.it.

Abstract:

We investigated whether polyphenols modulate the expression and activity of the enzymes gelatinases A (MMP-2) and B (MMP-9), involved in the pathogenesis of multiple sclerosis (MS). LPS-activated primary rat astrocytes were treated with the flavonoids quercetin (QRC) and cathechins [green tea extract (GTE)] and the non-flavonoids resveratrol (RSV) and tyrosol/hydroxytyrosol (Oliplus). As assessed by zymography and RT-PCR, RSV and Oliplus, but not QRC and GTE, dose-dependently inhibited the LPS-induced levels and mRNA expression of MMP-2 and MMP-9. By contrast, in cell-free systems direct inhibition of gelatinase activity in MS sera was determined by QRC and GTE, but not by RSV. Oliplus was only partially effective. Our results indicate that the flavonoids and non-flavonoids tested exert their inhibitory effect on MMPs, displaying different mechanisms of action, possibly related to their structure. Therefore, their combined use may represent a powerful tool for the down-regulation of MMPs in the course of MS.

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