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Article Publish Status: FREE
Abstract Title:

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases.

Abstract Source:

Front Pharmacol. 2020 ;11:153. Epub 2020 Feb 28. PMID: 32184728

Abstract Author(s):

Chunxu Luo, Lin Zou, Huijun Sun, Jinyong Peng, Cong Gao, Liuchi Bao, Renpeng Ji, Yue Jin, Shuangyong Sun

Article Affiliation:

Chunxu Luo

Abstract:

Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The anti-inflammatory effects of RosA have been revealed throughandstudies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the anti-inflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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