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Abstract Title:

A review of anti-tumour effects of ginsenoside in gastrointestinal cancer.

Abstract Source:

J Pharm Pharmacol. 2021 Apr 9. Epub 2021 Apr 9. PMID: 33836068

Abstract Author(s):

Jing Xu, Yunxia Pan, Yanyan Liu, Sha Na, Hui Zhou, Lu Li, Fengyuan Chen, Hang Song

Article Affiliation:

Jing Xu

Abstract:

OBJECTIVES: Gastrointestinal cancer, one of the major causes of cancer-related deaths in the world, refers to malignant conditions of the gastrointestinal (GI) tract and other organs. Although conventional therapy has been successful to some extent in cancer treatment, drug resistance and cancer recurrence still limit the therapeutic efficacy. There is increasing evidence indicating that ginsenoside, as a kind of high nutritional value and widely used traditional Chinese medicine, could contribute to the promotion of treatment in GI cancer, which deserves further investigation.

KEY FINDINGS: Based on previous studies, the possible mechanisms mainly include regulation of autophagy, apoptosis, proliferation, migration and angiogenesis. However, no studies recently have conducted a more in-depth review of the anti-cancer effects of ginsenoside in GI cancer.

SUMMARY: Therefore, this review will summarise and analyse the latest developments in the anti-tumour effects of ginsenosides in GI cancer, thus may promote further research of the anti-tumour efficacy of ginsenoside.

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Sayer Ji
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