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Article Publish Status: FREE
Abstract Title:

The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment.

Abstract Source:

Nutrients. 2017 Dec 17 ;9(12). Epub 2017 Dec 17. PMID: 29258206

Abstract Author(s):

Daniel Pereira Bezerra, Gardenia Carmen Gadelha Militão, Mayara Castro de Morais, Damião Pergentino de Sousa

Article Affiliation:

Daniel Pereira Bezerra

Abstract:

The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products. Eugenol has a dual effect on oxidative stress, which can action as an antioxidant or prooxidant agent. In addition, it has anti-carcinogenic, cytotoxic and antitumor properties. Considering the importance of eugenol in the area of food and human health, in this review, we discuss the role of eugenol on redox status and its potential use in the treatment and prevention of cancer.

Study Type : Review

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Sayer Ji
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