Article Publish Status: FREE
Abstract Title:

Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy.

Abstract Source:

J Exp Pharmacol. 2018 ;10:19-28. Epub 2018 Jun 22. PMID: 29950907

Abstract Author(s):

Basak Donertas, Cigdem Cengelli Unel, Kevser Erol

Article Affiliation:

Basak Donertas


Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well-known side effect of cisplatin and has the potential to result in limiting and/or reducing the dose, decreasing the quality of life. Unfortunately, the mechanism for cisplatin-induced neuropathy has not been completely elucidated. Currently, available treatments for neuropathic pain (NP) are mostly symptomatic, insufficient and are often linked with several detrimental side effects; thus, effective treatments are needed. Cannabinoids and agmatine are endogenous modulators that are implicated in painful states. This review explains the cisplatin-induced neuropathy and antinociceptive effects of cannabinoids and agmatine in animal models of NP and their putative therapeutic potential in cisplatin-induced neuropathy.

Study Type : Review

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