Abstract Title:

Gut-Brain Axis in Gastric Mucosal Damage and Protection.

Abstract Source:

Curr Neuropharmacol. 2016 Feb 23. Epub 2016 Feb 23. PMID: 26903151

Abstract Author(s):

Dolores Sgambato, Annalisa Capuano, Maria Giuseppa Sullo, Agnese Miranda, Alessandro Federico, Marco Romano

Article Affiliation:

Dolores Sgambato


The gut-brain axis plays a potential role in numerous physiological and pathological conditions. In particular, there are several substances and a dense neuronal network that link stomach with Central Nervous System (CNS). Several communication mechanisms involve spinal and vagal system. In particular, hypothalamo-pituitary-adrenocortical (HPA) axis, thyrotropin-releasing hormone (TRH)-containing nerve fibers and capsaicin-sensitive nerves are principal mediators of the harmful and protective CSN-mediated effects on gastric mucosa. Also, existing evidence indicates that nitric oxide (NO), prostaglandins (PGs) and calcitonin gene-related peptide (CGRP) play a role as final effectors of gastric protection. This review is focused on the role of gut-brain axis in gastric damage and protection and, in particular, on the role of steroids, TRH, PGs, melatonin, hydrogen sulfide (H2S) and peptides influencing food intake (leptin, cholecystokinin (CCK), peptide YY, central glucagon-like peptide-1 [GLP-1], ghrelin). Also, the role of GABAergic and glutamatergic pathways in gastric mucosal protection have been examined.

Study Type : Review
Additional Links
Pharmacological Actions : Gastroprotective : CK(534) : AC(228)
Additional Keywords : Gut-brain Axis : CK(52) : AC(18)

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