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Article Publish Status: FREE
Abstract Title:

Ginger (Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence.

Abstract Source:

Evid Based Complement Alternat Med. 2019 ;2019:5054395. Epub 2019 Aug 20. PMID: 31531114

Abstract Author(s):

Nur Fatin Nabilah Mohd Sahardi, Suzana Makpol

Article Affiliation:

Nur Fatin Nabilah Mohd Sahardi

Abstract:

Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer's disease (AD), Parkinson's disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines and reduce cellular antioxidant capacity. Increased oxidative stress levels beyond the production of antioxidant agents cause oxidative damage to biological molecules, including DNA, protein, and carbohydrates, which affects normal cell signalling, cell growth, differentiation, and apoptosis and leads to disease pathogenesis. Since oxidative stress and inflammation contribute to these diseases, ginger (Roscoe) is one of the potential herbs that can be used to reduce the level of oxidative stress and inflammation. Ginger consists of two major active components, 6-gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation. Thus, this paper will review the effects of ginger on ageing and degenerative diseases, including AD, PD, type 2 diabetes mellitus (DM), hypertension, and osteoarthritis.

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